Journal article
Vitamin D over the first decade and susceptibility to childhood allergy and asthma
EM Hollams, SM Teo, M Kusel, BJ Holt, KE Holt, M Inouye, NH De Klerk, G Zhang, PD Sly, PH Hart, PG Holt
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2017
Abstract
Background Vitamin D (25(OH)D) deficiency has been implicated as a possible risk factor for asthma development, but studies at selected time points measuring 25(OH)D levels during childhood have yielded conflicting findings. Prospective studies tracking 25(OH)D levels during the initiation phase of asthma in early childhood have not been reported. Objective We sought to elucidate relationships between 25(OH)D levels from birth to age 10 years and susceptibility to allergic sensitization, respiratory tract infections, and asthma. Methods Asthma-, allergy-, and respiratory tract infection–associated phenotypes (including pathogen identification) were characterized in a high-risk birth cohort. ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by Asthma Australia, the Western Australian Department of Health, and the NHMRC of Australia, including project grants #1026411 and #1049539 and fellowships #1061409 (to K.E.H.) and #1061435 (to M.I., cofunded with the Australian Heart Foundation).