Journal article

Multiple training interventions significantly improve reproducibility of PET/CT-based lung cancer radiotherapy target volume delineation using an IAEA study protocol

Tom Konert, Wouter V Vogel, Sarah Everitt, Michael P MacManus, Daniela Thorwarth, Elena Fidarova, Diana Paez, Jan-Jakob Sonke, Gerard G Hanna



BACKGROUND AND PURPOSE: To assess the impact of a standardized delineation protocol and training interventions on PET/CT-based target volume delineation (TVD) in NSCLC in a multicenter setting. MATERIAL AND METHODS: Over a one-year period, 11 pairs, comprised each of a radiation oncologist and nuclear medicine physician with limited experience in PET/CT-based TVD for NSCLC from nine different countries took part in a training program through an International Atomic Energy Agency (IAEA) study (NCT02247713). Teams delineated gross tumor volume of the primary tumor, during and after training interventions, according to a provided delineation protocol. In-house developed software recorded the pe..

View full abstract


Funding Acknowledgements

The authors would like to thank Heloisa Carvalho and Paolo Duarte (Institute do Cancer do Estado de Sao Paulo), Camilla Mosci and Carlos Zuliani (Hospital das Clinicas UNICAMP), Darja Altuhhova and Liina Karusoo (North Estonia Medical Center), Rakesh Kapoor and Ashwani Sood (Postgraduate Institute of Medical Education and Research), Jamal Khader and Akram Al-Ibraheem (King Hussein Cancer Center), Shahid Abubaker and Muhammad Numair (Institute of Nuclear Medicine and Oncology), Bozena Birkenfeld and Bartlomiej Masojc (Zachodniopomorskie Centrum Onkologii), Cigdem Soydal and Tugce Kutuk (Ankara University School of Medicine), Aldo Quarnetti and Omar Alonso (Centro Uruguayo de Imagenologia Molecular), Quang Bieu Bui and Ngoc Ha Le (Tran Hung Dao General Hospital), Nguyen Xuan Canh and Tuan Anh Le (Cho Ray Hospital) for their active cooperation in the study. The authors also wish to thank Marcel van Herk for the support with the Big Brother software in this study.