Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections
Stefano G Giulieri, Natasha E Holmes, Timothy P Stinear, Benjamin P Howden
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | TAYLOR & FRANCIS LTD | Published : 2016
INTRODUCTION: Management of invasive Staphylococcus aureus infections is complex. Dramatic improvements in bacterial whole genome sequencing (WGS) offer new opportunities for personalising the treatment of S. aureus infections. Areas covered: We address recent achievements in S. aureus genomics, describe genetic determinants of antibiotic resistance and summarise studies that have defined molecular characteristics associated with risk and outcome of S. aureus invasive infections. Potential clinical use of WGS for resistance prediction, infection outcome stratification and management of persistent /relapsing infections is critically discussed. Expert commentary: WGS is not only providing inva..View full abstract
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Awarded by National Health and Medical Research Council, Australia
This paper was supported by the National Health and Medical Research Council, Australia [grant numbers: 1008549, 1073378, 1105905] and the SICPA Foundation, Switzerland.