Journal article

MRI-negative temporal lobe epilepsy A network disorder of neocortical connectivity

David N Vaughan, Genevieve Rayner, Chris Tailby, Graeme D Jackson



OBJECTIVE: To define the functional network changes that characterize MRI-negative temporal lobe epilepsy (TLE) and TLE with hippocampal sclerosis (HS-TLE). METHODS: We studied 36 patients with medically refractory unilateral TLE, having either a normal clinical MRI (n = 18) or unilateral hippocampal sclerosis (n = 18). Patients were compared to healthy controls of equivalent age and sex (n = 27). Functional connectivity in 10 minutes of task-free functional MRI was assessed using a voxel-resolution graph theoretic analysis, using the metrics of degree, clustering coefficient, eigenvector, and betweenness centrality. Significant clusters were further explored with a seed-based analysis. RESU..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC practitioner fellowship

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952 and project grant 1081151), a computation grant from the Victorian Life Sciences Computation Initiative, and the Victorian Government Operational Infrastructure Support Program. Some participant scans were funded by an Austin Health Medical Research Foundation Grant awarded to G.R. and Professor Sarah Wilson at the University of Melbourne, and by a Rebecca L. Cooper Medical Research Foundation Grant awarded to C.T. D.N.V. was supported by an NHMRC Postgraduate Scholarship and a Windermere Foundation Doctoral Scholarship. G.D.J. is supported by an NHMRC practitioner fellowship (1060312).