Mechanisms of memory impairment in epilepsy depend on age at disease onset
Genevieve Rayner, Graeme D Jackson, Sarah J Wilson
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
OBJECTIVE: In this study, we aimed to uncover distinct antecedents of autobiographic memory dysfunction in patients with epilepsy with early (childhood/adolescence) vs late (adulthood) disease onset. METHODS: One hundred sixty-six adults participated: 92 patients with focal epilepsy, whose cognitive and psychiatric functioning were compared to that of 74 healthy controls. Predictors of autobiographic memory deficit were contrasted between patients with early-onset (n = 47) vs late-onset (n = 45) epilepsy. RESULTS: Overall, people with epilepsy performed significantly worse on measures of both semantic and episodic autobiographic memory and showed markedly high rates of depressive symptoms an..View full abstract
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Awarded by NHMRC
The work of G.J. is supported by an NHMRC Program Grant (400121), an NHMRC Practitioner Fellowship (527800), and by a Victorian Government Operational Infrastructure Support Grant.