Journal article
The receptor for advanced glycation end products (RAGE) is associated with persistent atrial fibrillation
TF Lancefield, SK Patel, M Freeman, E Velkoska, B Wai, PM Srivastava, M Horrigan, O Farouque, LM Burrell
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Objective Upregulation of the receptor for advanced glycation end products (RAGE) has been proposed as a pathophysiological mechanism underlying the development of atrial fibrillation (AF).We sought to investigate if soluble RAGE levels are associated with AF in Caucasian patients. Methods Patients (n = 587) were prospectively recruited and serum levels of soluble RAGE (sRAGE) and endogenous secretoryRAGE (esRAGE) measured. The patients included 527 with sinus rhythm, 32 with persistent AF (duration >7 days, n = 32) and 28 with paroxysmal AF (duration <7 days, n = 28). Results Patients with AF were older and had a greater prevalence of heart failure than patients in sinus rhythm. Circulating..
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Funding Acknowledgements
This work was supported by the National Heart Foundation Clinical Research Scholarship (http://heartfoundation.org.au) to TL and the Pfizer Cardiovascular Lipid grant (https://www.pfizergrants.com.au/grants/CardiovascularLipid.aspx) to TL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.