Journal article
Spatial effects on the multiplicity of Plasmodium falciparum infections
S Karl, MT White, GJ Milne, D Gurarie, SI Hay, AE Barry, I Felger, I Mueller
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
As malaria is being pushed back on many frontiers and global case numbers are declining, accurate measurement and prediction of transmission becomes increasingly difficult. Low transmission settings are characterised by high levels of spatial heterogeneity, which stands in stark contrast to the widely used assumption of spatially homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable human exposure and duration of infection, limited mosquito flight distance and most importantly geographically heterogeneous human and mosquito population ..
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Awarded by Medical Research Council
Funding Acknowledgements
SK, AB and IM acknowledge support from the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. SK was supported by an NHMRC (Australia) Early Career Fellowship (GNT 1052760). MTW was supported by an MRC (UK) Research Fellowship. The authors thank all researchers and study participants involved in the PNG studies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.