Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation
Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016
Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced soluble mediators. During the mid-secretory (MS) phase of the menstrual cycle, increased glandular secretion into the uterine lumen provides important mediators that modulate the endometrium and support the conceptus during implantation. Previously we demonstrated the importance of vascular endothelial growth factor (VEGF) in the human uterus, particularly with respect to embryo implantation. In the current study, proteomic analysis of human uterine lavage fluid identified the presence of placental growth factor (PlGF) a homolog of VEGF, that binds the VEGF recep..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by a University of Melbourne Early Career Researcher Grant #601040 and the National Health and Medical Research Council of Australia Fellowships (#1002028 to LAS, # 628927 to NJH) and project (#1047056) grants. Work at the Hudson Institute was also supported by Monash IVF Research and Education Foundation and the Victorian Government's Operational Infrastructure Program. NKB was supported by an Australian Postgraduate Award.