Journal article
Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat β-glucan
P Gunness, J Michiels, L Vanhaecke, S De Smet, O Kravchuk, A Van De Meene, MJ Gidley
FASEB Journal | FEDERATION AMER SOC EXP BIOL | Published : 2016
Abstract
Although oat (1,3:1,4)-β-glucan (BG) has been shown to decrease blood cholesterol in intervention trials, the detailed mechanism is not yet defined, but restricted reabsorption of bile acids (BAs) has been hypothesized. Using pigs as a model for humans we demonstrated that, compared to the control, BG added to the diet for 26 d caused decreases of 24% in blood total BAs (TBAs), 34% in total cholesterol (TC), and 57% in LDL cholesterol (LDL-C) (P < 0.01); decreases of 20% TBAin the midjejunum and terminal ileum(P < 0.01); increases of 80% in cecal total neutral sterols (TNSs) including cholesterol (P < 0.01); a 50% reduction in BA active transport across ex vivo ileum after 40 min (P < 0.001)..
View full abstractGrants
Awarded by Australian Research Council
Funding Acknowledgements
The authors thank the staff of the Departments of Applied Biosciences and Animal Production (Faculty of Bioscience Engineering, Ghent University), for setting up of the animal facilities and pens and their help with experiments. This study was supported by Australian Research Council Grant CE110001007 to the Centre of Excellence in Plant Cell Walls.