Journal article

ANGIOTENSIN-II RECEPTOR-BINDING AND THE BAROREFLEX PATHWAY

AM ALLEN, MJ MCKINLEY, BJ OLDFIELD, RAL DAMPNEY, FAO MENDELSOHN

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | MARCEL DEKKER INC | Published : 1988

Abstract

Angiotensin II (Ang II) acts centrally to modulate autonomic activity and cardiovascular function. Using in vitro autoradiography we have determined the distribution of putative receptors for ANG II in brain regions associated with the baroreflex pathway. Ang II receptor binding sites were observed in the nucleus of the solitary tract (NTS), the dorsal motor nucleus of vagus, the rostral and caudal ventrolateral medulla and intermediolateral cell column of the spinal cord. Receptor binding sites were also observed in the nodose ganglion and in association with nerve fibres in the heart. Nodose ganglionectomy and vagal ligation studies revealed that Ang II receptor binding sites are produced ..

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