Physiological actions of angiotensin II mediated by AT1 and AT2 receptors in the brain.
MJ McKinley, RM McAllen, GL Pennington, A Smardencas, RS Weisinger, BJ Oldfield
Clin Exp Pharmacol Physiol Suppl | Published : 1996
1. Autoradiographic binding studies have shown that the AT1 receptor is the predominant angiotensin II (AngII) receptor subtype in the central nervous system (CNS). Major sites of AT1 receptors are the lamina terminalis, hypothalamic paraventricular nucleus, the lateral parabrachial nucleus, rostral and caudal ventrolateral medulla, nucleus of the solitary tract and the intermediolateral cell column of the thoraco-lumbar spinal cord. 2. While there are differences between species, AT2 receptors are found mainly in the cerebellum, inferior olive and locus coeruleus of the rat. 3. Circulating AngII acts on AT1 receptors in the subfornical organ and organum vasculosum of the lamina terminalis (..View full abstract