Journal article

A quantum spin-probe molecular microscope

VS Perunicic, CD Hill, LT Hall, LCL Hollenberg

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2016

Abstract

Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule using a quantum spin probe acting simultaneously as the magnetic resonance sensor and source of magnetic field gradient. Signals corresponding to specific regions of the molecule's nuclear spin density are encoded on the quantum state of the probe, which is used to produce a 3D image of the molecular structure. Quantum simulations of the protocol applied to the rapamycin molecule..

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Grants

Awarded by Australian Research Council (ARC) under the Centre of Excellence scheme


Awarded by ARC Laureate Fellowship


Funding Acknowledgements

We thank J.-P. Tetienne, D. Simpson, A. Stacey and M. Usman for useful discussions. This work was partly supported by the Australian Research Council (ARC) under the Centre of Excellence scheme (project number CE110001027). L.C.L.H. acknowledges an ARC Laureate Fellowship (FL130100119).