Journal article

Characterization of a Secretory Annexin in Echinococcus granulosus

Xingju Song, Dandan Hu, Xiuqin Zhong, Ning Wang, Xiaobin Gu, Tao Wang, Xuerong Peng, Guangyou Yang

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | AMER SOC TROP MED & HYGIENE | Published : 2016

Abstract

Cystic echinococcosis, caused by Echinococcus granulosus, is a widespread parasitic zoonosis causing economic loss and public health problems. Annexins are important proteins usually present in the plasma membrane, but previous studies have shown that an annexin B33 protein of E. granulosus (Eg-ANX) could be detected in the excretory/secretory products and cyst fluid. In this study, we cloned and characterized Eg-ANX. In silico analysis showed that the amino acid sequence of Eg-ANX was conserved and lacked any signal peptides. The phospholipid-binding activity of recombinant Eg-ANX (rEg-ANX) was tested; liposomes could bind to rEg-ANX only in the presence of Ca(2+). In addition, we performed..

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University of Melbourne Researchers