Journal article
Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling
TM Furlong, JR Duncan, LH Corbit, CD Rae, BD Rowlands, AD Maher, FA Nasrallah, CJ Milligan, S Petrou, AJ Lawrence, BW Balleine
Journal of Neurochemistry | WILEY-BLACKWELL | Published : 2016
DOI: 10.1111/jnc.13858
Abstract
Toluene is a commonly abused inhalant that is easily accessible to adolescents. Despite the increasing incidence of use, our understanding of its long-term impact remains limited. Here, we used a range of techniques to examine the acute and chronic effects of toluene exposure on glutameteric and GABAergic function, and on indices of psychological function in adult rats after adolescent exposure. Metabolomics conducted on cortical tissue established that acute exposure to toluene produces alterations in cellular metabolism indicative of a glutamatergic and GABAergic profile. Similarly, in vitro electrophysiology in Xenopus oocytes found that acute toluene exposure reduced NMDA receptor signal..
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Awarded by Australian Research Council
Funding Acknowledgements
The research reported in this paper was supported by the National Health and Medical Research Council of Australia, of which BWB is Senior Principal Research Fellow (1079561), AJL a Principal Research Fellow (1020737) and CDR a Senior Research Fellow (630516), contributions from project grant (568767); by grants from the Australian Research Council (FL0992409 to BWB and DP110100379 to JRD) and of which JRD was a Future Fellow during the time of the study (FF100100235); and by the Victorian Government's Operational Infrastructure Support Scheme. The funding sources had no involvement in the design, analysis and decision to publish. The authors declare no conflicts of interest.