Journal article

MICROALBUMINURIA - PROGNOSTIC AND THERAPEUTIC IMPLICATIONS IN DIABETES-MELLITUS

RE GILBERT, ME COOPER, PG MCNALLY, RC OBRIEN, J TAFT, G JERUMS

Diabetic Medicine | JOHN WILEY & SONS LTD | Published : 1994

Abstract

Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excre..

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