Journal article

Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia

David GS Farmer, Mathias Dutschmann, Julian FR Paton, Anthony E Pickering, Robin M McAllen



KEY POINTS: Cardiac vagal tone is a strong predictor of health, although its central origins are unknown. Respiratory-linked fluctuations in cardiac vagal tone give rise to respiratory sinus arryhthmia (RSA), with maximum tone in the post-inspiratory phase of respiration. In the present study, we investigated whether respiratory modulation of cardiac vagal tone is intrinsically linked to post-inspiratory respiratory control using the unanaesthetized working heart-brainstem preparation of the rat. Abolition of post-inspiration, achieved by inhibition of the pontine Kolliker-Fuse nucleus, removed post-inspiratory peaks in efferent cardiac vagal activity and suppressed RSA, whereas substantial ..

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Awarded by Australian Research Council

Awarded by British Heart Foundation

Awarded by Wellcome Trust

Awarded by NHMRC

Funding Acknowledgements

This work was funded by the Australian Research Council (DP130104661) and a grant from the Faculty of Medicine, University of Melbourne. DGSF was funded by the Australian Research Council (DP130104661). JFRP is funded by the British Heart Foundation (RG/12/6/29670). AEP is a Wellcome Trust Senior Clinical fellow (gr088373). MD is supported by an Australasian Research Council Future Fellowship (FT120100953). RMM was funded in part by a Fellowship from the NHMRC (566667). We also acknowledge the support of the Victorian Government through the Operational Infrastructure Scheme.