Journal article

Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia

David GS Farmer, Mathias Dutschmann, Julian FR Paton, Anthony E Pickering, Robin M McAllen

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2016

Abstract

KEY POINTS: Cardiac vagal tone is a strong predictor of health, although its central origins are unknown. Respiratory-linked fluctuations in cardiac vagal tone give rise to respiratory sinus arryhthmia (RSA), with maximum tone in the post-inspiratory phase of respiration. In the present study, we investigated whether respiratory modulation of cardiac vagal tone is intrinsically linked to post-inspiratory respiratory control using the unanaesthetized working heart-brainstem preparation of the rat. Abolition of post-inspiration, achieved by inhibition of the pontine Kolliker-Fuse nucleus, removed post-inspiratory peaks in efferent cardiac vagal activity and suppressed RSA, whereas substantial ..

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Grants

Awarded by Australian Research Council


Awarded by British Heart Foundation


Awarded by Wellcome Trust


Awarded by NHMRC


Funding Acknowledgements

This work was funded by the Australian Research Council (DP130104661) and a grant from the Faculty of Medicine, University of Melbourne. DGSF was funded by the Australian Research Council (DP130104661). JFRP is funded by the British Heart Foundation (RG/12/6/29670). AEP is a Wellcome Trust Senior Clinical fellow (gr088373). MD is supported by an Australasian Research Council Future Fellowship (FT120100953). RMM was funded in part by a Fellowship from the NHMRC (566667). We also acknowledge the support of the Victorian Government through the Operational Infrastructure Scheme.