Journal article
Risk factors for development of pulmonary arterial hypertension in Australian systemic sclerosis patients: Results from a large multicenter cohort study
K Morrisroe, M Huq, W Stevens, C Rabusa, SM Proudman, M Nikpour
BMC Pulmonary Medicine | BMC | Published : 2016
Abstract
Background: Pulmonary arterial hypertension (PAH) is the leading cause of mortality in patients with systemic sclerosis (SSc). We sought to determine the incidence, prevalence and risk factors for PAH development in a large Australian SSc cohort. Methods: PAH was diagnosed on right heart catheterisation (mPAP >25 and PAWP <15 mmHg at rest). Patients with PH secondary to interstitial lung disease (ILD; defined as abnormal HRCT scan and FVC < 60 %) were excluded. Summary statistics, chi-square tests, univariate and multivariable logistic regression along with post-estimation diagnostics were used to determine the associations of different combinations of risk factors with PAH. Results: Among 1..
View full abstractGrants
Awarded by Bristol-Myers Squibb
Funding Acknowledgements
This work was supported by Scleroderma Australia, Arthritis Australia, Actelion Australia, Bayer, CSL Biotherapies, GlaxoSmithKline Australia, Pfizer and BMS. Dr Morrisroe is a recipient of an RACP Shields Fellowship, an Australian Rheumatology Association (Vic) 'top-up' PhD scholarship and an NHMRC Postgraduate Scholarship (APP1113954). Dr Nikpour is supported by a University of Melbourne Faculty of Medicine Dentistry and Health Science David Bickart Clinician Researcher Fellowship and is a recipient of an NHMRC Fellowship (APP1071735).