Journal article
Determinants of Neonatal Vitamin D Levels as Measured on Neonatal Dried Blood Spot Samples
CA Smith, C Sun, A Pezic, C Rodda, F Cameron, K Allen, ME Craig, J Carlin, T Dwyer, RM Lucas, DW Eyles, AS Kemp, JA Ellis, AL Ponsonby
Neonatology | KARGER | Published : 2017
DOI: 10.1159/000448680
Abstract
Background: Vitamin D deficiency is linked to adverse childhood health outcomes, yet data on the distribution and quantifiable determinants of neonatal 25-hydroxyvitamin D3 (25OHD) concentration, a vitamin D biomarker, are limited. Objective: Our aim was to identify determinants of neonatal 25OHD concentration, measured using neonatal dried blood spots (DBS). Methods: A total of 259 ethnically diverse children aged 0-16 years born in Victoria, Australia, were recruited. Data included maternal sun exposure, skin type, 25OHD concentration on stored neonatal DBS, and genotypes at the target genes. Associations were investigated using multiple linear regression models. Results: The median 25OHD ..
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Funding Acknowledgements
We thank the families, research nurses and research assistants who participated in this study. We acknowledge support from the Australian National Health and Medical Research Council (NHMRC), Financial Markets Foundation for Children, Diabetes Australia Research Trust, the Australian Research Council, Arthritis Australia, Rebecca L Cooper Foundation, LEW Carty Charitable Fund, ANZ Medical Research and Technologies in Victoria Fund, Lynne Quayle Charitable Trust, Victorian State Government Operational Infrastructure Support Program, and Murdoch Childrens Research Institute. A.L.P. and R.M.L. were supported by NHMRC Senior Research Fellowships. J.A.E. was supported by an ARC Future Fellowship. C.S. was supported by an NHMRC Early Career Research Fellowship.