Journal article

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells

Kevin V Chow, Robyn M Sutherland, Yifan Zhan, Andrew M Lew

IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2017

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that consist of functionally and phenotypically heterogeneous populations. Monocyte-derived DCs (moDCs) are a DC subset that have been attracting increasing interest owing to their potent influence on adaptive immune function and their rapid accumulation upon an inflammatory stimulus. Although early studies on moDCs mainly addressed infection, their emergence and function in other settings such as autoimmunity and allogeneic organ transplantation are now being increasingly appreciated. In this review, the relationship between murine monocyte subsets and the moDCs that arise from them is discussed. Their role in initiating and mo..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC Independent Research Institutes Infrastructure Support Scheme grant


Funding Acknowledgements

This work was supported by Rebecca L Cooper Foundation, National Health and Medical Research Council of Australia (NHMRC) grants (1037321, 1043414, 1080321 and 1105209), NHMRC Independent Research Institutes Infrastructure Support Scheme grant (361646) and Victorian State Government Operational Infrastructure Support grant. KVC has received a Kidney Health Australia Biomedical Scholarship and an NHMRC Postgraduate Scholarship. We acknowledge the Wurundjeri people of the Kulin nation as the traditional owners and custodians of the land on which most of the work was performed.