Journal article
Two benzimidazole resistance-associated SNPs in the isotype-1 beta-tubulin gene predominate in Haemonchus contortus populations from eight regions in China
Zongze Zhang, Robin B Gasser, Xin Yang, Fangyuan Yin, Guanghui Zhao, Min Bao, Baoliang Pan, Weiyi Huang, Chunren Wang, Fengcai Zou, Yanqin Zhou, Junlong Zhao, Rui Fang, Min Hu
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2016
Abstract
Haemonchus contortus is one of the most important parasitic nematodes of small ruminants around the world, particularly in tropical and subtropical regions. The control of haemonchosis relies mainly on anthelmintics, but the excessive and prolonged use of anthelmintics is causing serious drug resistance issues in many countries. As benzimidazole (BZ) anthelmintics have been broadly used in China, we hypothesized that resistance is widespread. Given the link between three known single nucleotide polymorphisms (SNPs, designated F167Y, E198A and F200Y) in the isotype-1 β-tubulin gene and BZ resistance, our goal here was to explore the presence of these mutations in H. contortus from small rumin..
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Awarded by National Key Basic Research Program (973 Program) of China
Awarded by Special Fund for Agro-Scientific Research in the Public Interest
Awarded by Huazhong Agricultural University Scientific & Technological Self-innovation Foundation
Funding Acknowledgements
This study was supported by the "National Key Basic Research Program (973 Program) of China" (Grant No. 2015CB150300) and the "Special Fund for Agro-Scientific Research in the Public Interest" (Grant no. 201303037). Funding from Huazhong Agricultural University Scientific & Technological Self-innovation Foundation (Program No. 2015RC005), the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) and Melbourne Water Corporation is gratefully acknowledged (RBG).