Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects
Mattias Bjornmalm, Matthew Faria, Xi Chen, Jiwei Cui, Frank Caruso
LANGMUIR | AMER CHEMICAL SOC | Published : 2016
The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although standard static cell cultures remain the norm for in vitro studies, modern models mimicking aspects of the dynamic in vivo environment have been developed. Herein, we investigate fundamental cell-particle interactions under dynamic flow conditions using a simple and self-contained device together with standard multiwell cell culture plates. We engineer two particle systems and evaluate their cell interactions under dynamic flow, and we compare the results to standard static cell cultures. We find substantial differences between static and dynamic flow conditions a..View full abstract
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Awarded by Australian Research Council (ARC) under the Australian Laureate Fellowship Scheme
Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
This work was supported by the Australian Research Council (ARC) under the Australian Laureate Fellowship Scheme (F.C., FL120100030) and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We acknowledge Paul Brannon for help with confocal microscopy imaging.