Journal article
Distinct subcortical volume alterations in pediatric and adult OCD: A worldwide meta- and mega-analysis
PSW Boedhoe, L Schmaal, Y Abe, SH Ameis, PD Arnold, MC Batistuzzo, F Benedetti, JC Beucke, I Bollettini, A Bose, S Brem, A Calvo, Y Cheng, KI Cho, S Dallaspezia, D Denys, KD Fitzgerald, JP Fouche, M Giménez, P Gruner Show all
American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2017
Abstract
Objective: Structural brain imaging studies in obsessivecompulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted metaand mega-analyses of data from OCD sites worldwide. Method: T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCDpatientsandhealthy subjects.Theauthorsperformedametaanalysis on themean of the left and right hemisphere..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
The ENIGMA OCD Working Group gratefully acknowledges support from the NIH BD2K award U54 EB020403-02 (principal investigator, Dr. Thompson). Supported by the Neuroscience Campus Amsterdam, IPB-grant to Dr. Schmaal and Dr. van den Heuvel; the Hartmann Muller Foundation (No. 1460 to Dr. Brem); the International Obsessive-Compulsive Disorder Foundation Research Award to Dr. Gruner; the Deutsche Forschungsgemeinschaft (KO 3744/2-1 to Dr. Koch); the Marato TV3 Foundation grants 01/2010 and 091710 to Dr. Lazaro; the Wellcome Trust and a pump priming grant from the South London and Maudsley Trust, London (project grant no. 064846) to Dr. Mataix-Cols; the Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT KAKENHI No. 26461753 to Dr. Nakamae); Government of India grants to Prof. Reddy (SR/S0/HS/0016/2011) and Dr. Narayanaswamy (DST INSPIRE faculty grant -IFA12-LSBM-26) of the Department of Science and Technology; the Government of India grants to Prof. Reddy (No.BT/PR13334/Med/30/259/2009) and Dr. Narayanaswamy (BT/06/IYBA/2012) of the Department of Biotechnology; the Wellcome-DBT India Alliance grant to Dr. Venkatasubramanian (500236/Z/11/Z); the Carlos III Health Institute (CP10/00604, PI13/00918, PI13/01958, PI14/00413/PI040829); FEDER funds/European Regional Development Fund, AGAUR (2014 SGR 1672 and 2014 SGR 489); a "Miguel Server" contract (CP10/00604) from the Carlos III Health Institute to Dr. Soriano-Mas; the Italian Ministry of Health (RC10-11-12-13-14-15A to Dr. Spalletta); the Swiss National Science Foundation (No. 320030_130237 to Dr. Walitza); and the Netherlands Organization for Scientific Research (NWO VIDI 917-15-318 to Dr. van Wingen). Dr. Menchon has received grants and served as consultant, adviser, or speaker for AB-Biotics, Ferrer, GlaxoSmithKline, Janssen, Lundbeck, Medtronic, Otsuka, and the Spanish Ministry of Science and Innovation (CIBERSAM). Dr. Minuzzi has received grant or research support from the Alternative Funding Plan Innovation Fund, the Brain and Behavioral Foundation, the Canadian Institutes of Health Research, the Hamilton Health Sciences Foundation, the Ontario Brain Institute, and the Ontario Mental Health Foundation; he has served as a consultant or speaker for Bristol-Myers Squibb, the Canadian Psychiatric Association, the Canadian Network for Mood and Anxiety Treatments, and Lundbeck. Dr. Simpson receives royalties from Cambridge University Press and UpToDate. Prof. Dr. Walitza has received lecture honoraria from Opopharma and Eli Lilly; her work and research have been partially supported by the Swiss National Science Foundation, the German Research Foundation, Hochspezialisierte Medizin of the Canton of Zurich, and the German Federal Ministry of Education and Research. Dr. Stein has received research grants or consultancy honoraria from AMBRF, Biocodex, Cipla, Lundbeck, the National Responsible Gambling Foundation, Novartis, Servier, and Sun. Dr. van den Heuvel has received research funding (sponsor-initiated clinical trial) from PhotoPharmics and has served as a speaker for Lundbeck. The other authors report no financial relationships with commercial interests.