Journal article

REGULATION OF NEURAL PRECURSOR DIFFERENTIATION IN THE EMBRYONIC AND ADULT FOREBRAIN

PF BARTLETT, LR RICHARDS, TJ KILPATRICK, PS TALMAN, KA BAILEY, GJF BROOKER, R DUTTON, S KOBLAR, V NURCOMBE, M FORD, SS CHEEMA, V LIKIARDOPOULOS, M MURPHY

Clinical and Experimental Pharmacology and Physiology | BLACKWELL SCIENCE PUBL AUSTR | Published : 1995

Abstract

1. Precursors form the neuroepithelium of the developing cortex and also from the adult sub-ventricular zone, can be cloned in vitro after stimulation with fibroblast growth factor (FGF)-2 and have the potential to give rise to both neurons and glia. The generation of neurons from these clones can be stimulated by either a factor derived from an astrocyteprecursor line, Ast-1, or FGF-1. 2. Neuronal differentiation stimulated by FGF-1 can be inhibited by diacylglycerol-lipase inhibitor and mimicked by arachidonic acid, suggesting that the neuronal differentiation is signalled through the PCL gamma pathway. 3. The sequential expression of FGF-2 and FGF-1 within the developing forebrain neuroep..

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