Journal article

The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria

K Chotivanich, R Udomsangpetch, A Dondorp, T Williams, B Angus, JA Simpson, S Pukrittayakamee, S Looareesuwan, CI Newbold, NJ White

JOURNAL OF INFECTIOUS DISEASES | UNIV CHICAGO PRESS | Published : 2000

Abstract

Studies were conducted to determine how malaria parasites are cleared from the blood after antimalarial treatment. Neither artesunate nor quinine decreased parasitized red cell deformability or increased antibody binding. In acute falciparum malaria, ring-infected erythrocyte surface antigen (RESA) was observed in erythrocytes without malaria parasites (RESA-red blood cell [RBC]), indicating prior parasitization. In uncomplicated malaria, RESA-RBC numbers increased significantly (P=.002) within 24 h of starting artesunate but rose much more slowly (7 days) after quinine treatment. In severe malaria, RESA-RBC increased significantly (P=. 001) within hours of starting artesunate but not with q..

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