Journal article

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

Gabor G Kovacs, Isidro Ferrer, Lea T Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J Cairns, John F Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M Halliday, James W Ironside, Seth Love, Ian R Mackenzie, David G Munoz, Melissa E Murray, Peter T Nelson, Hitoshi Takahashi, John Q Trojanowski, Olaf Ansorge Show all

ACTA NEUROPATHOLOGICA | SPRINGER | Published : 2016

Abstract

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individu..

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Awarded by FP7 EU Project


Awarded by NIH


Awarded by NIA


Awarded by UK Medical Research Council (MRC)


Awarded by Grant Agency of Ministry of Health of Czech Republic


Awarded by National Institute of Neurological Disorders and Stroke


Awarded by National Institute of Aging Boston University Alzheimer's Disease Center


Awarded by UK Medical Research Council


Awarded by National Brain Research Program, Hungary


Awarded by Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III-Fondos FEDER


Awarded by DFG


Awarded by Johns Hopkins Alzheimer's Disease Research Center NIH


Awarded by Alzheimer's Disease Core Center Grant


Awarded by JSPS KAKENHI


Awarded by National Institute of Health Grants



Awarded by Grants-in-Aid for Scientific Research


Awarded by MRC


Awarded by Medical Research Council


Awarded by Parkinson's UK


Funding Acknowledgements

We are extremely grateful to the patients, clinicians, and fellow researchers that made this effort possible. We also acknowledge the following funding sources: FP7 EU Project Develage No. 278486 (GGK); Grant "NIH P30 AG10133 (BG); NIA Grants P50 AG05681, P01 AG03991 (NJC), NIH R01 AG040311, institutional Grants NIH P01 AG019724-03 and P50 AG023501, and the tau consortium (LTG); the Nelson Family Foundation (MEM) and NIH Grants P50 AG016574 and P50 NS072187 (MEM, DWD); NIH Grant AG010124, AG017586 (JQT); NIH Grant P50 AG005138 (PRH); Alzheimer's Research UK (ARUK), Alzheimer's Society, National Institute for Health Research (NIHR), and UK Medical Research Council (MRC; G0400074) (JA); GMH is a National Health and Medical Research Council of Australia Senior Principal Research Fellow (# 630434); Grant IGA NT12094-5 from Grant Agency of Ministry of Health of Czech Republic (RM); NIH Grant # AG028383 (PN); UK Medical Research Council (MRC; MR/L016400/1) (CS); NIA P50 AG005133 (JK); National Institute of Neurological Disorders and Stroke (1U01NS086659-01), Department of Veterans Affairs,), the National Institute of Aging Boston University Alzheimer's Disease Center (P30AG13846; supplement 0572063345-5) (ACM); UK Medical Research Council (MC-PC-13044) (JWI and CS); National Brain Research Program, Hungary (KTIA_13_NAP-A-II/7) and Grant-in-Aid (KAKEN 26250017) (both for TH); NIH Grant P30AG12300 (KH, CLW); Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III-Fondos FEDER, a way to build Europe FIS Grants PI14/00757 and PI14/00328 (IF); DFG Grant (SFB 1134/A03) (CS); Johns Hopkins Alzheimer's Disease Research Center NIH Grant # P50AG05146 (JCT); Alzheimer's Disease Core Center Grant P30AG008051-26 (TW); Grant AG13854 (EHB); JSPS KAKENHI Grant Number 26430060 (MT); Italian Ministry of Health (GG and FT); National Institute of Health Grants P50 AG05136 and P50 NS062684 (TJM). The help of Brain Banks in collecting tissue is also highly acknowledged: Vienna KIN-Neurobiobank and VITA-study (GGK); GIE NeuroCEB (funded by the patients associations France Alzheimer, France Parkinson, Fondacion ARSEP and CSC) (CD); Sydney Brain Bank (funded by Neuroscience Research Australia and the University of New South Wales) (GMH); the Sheffield and Cambridge Brain Banks (CFAS) (PI, SW); Parkinson's UK Tissue Bank at Imperial College, funded by Parkinson's UK, a charity registered in England and Wales (948776) and Scotland (SC037554) (SG); The Edinburgh Brain Bank is supported by the UK Medical Research Council (MR/L016400/1) (CS, JWI).