Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue
F Kreilaus, AS Spiro, CA McLean, B Garner, AM Jenner
Neuropathology and Applied Neurobiology | WILEY | Published : 2016
AIMS: Cholesterol plays an essential role in membrane structure and function, being especially important in the brain. Alteration of brain cholesterol synthesis and metabolism has been demonstrated in several Huntington's disease (HD) mouse and cell models; however, less is known about these alterations in human tissue. This study aimed to identify alterations to cholesterol synthetic and metabolic pathways in human HD brain tissue. METHODS: A broad range of cholesterol synthetic precursors, metabolites and oxidation products were measured by gas chromatography-tandem mass spectrometry in five regions of human post mortem HD brain and compared with age- and sex-matched control tissues. The l..View full abstract
Awarded by University of Wollongong
The study was funded by a University of Wollongong start up grant (#1030328). F Kreilaus acknowledges his scholarship funding by The University of Wollongong and The Illawarra Health and Medical Research Institute. Tissues were received from the Victorian Brain Bank, supported by The Florey Institute of Neuroscience and Mental Health, The Alfred and the Victorian Forensic Institute of Medicine and funded in part by Australia's National Health & Medical Research Council, Parkinson's Victoria and MND Victoria.