Journal article

Histological validation of cardiacmagnetic resonance analysis of regional and diffuse interstitial myocardial fibrosis

Leah M Iles, Andris H Ellims, Huw Llewellyn, James L Hare, David M Kaye, Catriona A McLean, Andrew J Taylor

European Heart Journal - Cardiovascular Imaging | OXFORD UNIV PRESS | Published : 2015

Abstract

AIM: Myocardial fibrosis is fundamental in the pathogenesis of heart failure. Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, especially in non-ischaemic cardiac disease. Diffuse interstitial myocardial fibrosis is increasingly recognized as central in the pathogenesis of cardiomyopathy and can be quantified using newer CMR techniques such as T1 mapping. We evaluated the relationship of CMR assessment of regional and diffuse fibrosis with human histology. METHODS AND RESULTS: Eleven patients on the waiting list for heart transplantation (43.5 ± 7.6 y..

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Grants

Funding Acknowledgements

L.M.I. is supported by a National Health and Medical Research Council Postgraduate Research Scholarship, Melbourne, Australia and a combined National Health and Medical Research Council and National Heart Foundation Early Career Fellowship, Melbourne, Australia. A.H.E. is supported by a combined Heart Foundation of Australia and National Heart and Medical Research Council Postgraduate Research Scholarship, Melbourne, Australia. J.L.H. is supported by a Cardiac Society of Australia and New Zealand Research Investigatorship. D.M.K. is supported by a National Health and Medical Research Council program grant. A.J.T. is supported by a National Health and Medical Research Council project grant.