Cholesterol involvement in the pathogenesis of neurodegenerative diseases
Jun-Ping Liu, Ying Tang, Shufeng Zhou, Ban Hock Toh, Catriona McLean, He Li
Molecular and Cellular Neuroscience | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010
Cholesterol, an essential component of cell membranes, plays an important role in the maintenance of cellular homeostasis and transmembrane communication within and between cellular compartments. In the brain that contains the highest levels of cholesterol in the body, cholesterol traffic occurs between nerve cells and between intracellular organelles in neurons to subserve normal brain function. Whereas glial cells produce the largest quantities of cholesterol, neurons also acquire cholesterol synthesized by astrocytes. The intracellular organelle endosomes and lysosomes receive and distribute cholesterol through the endocytic and retrograde transport pathways. However, deregulated choleste..View full abstract
This work was Supported by grants from the National Health and Medical Research Council of Australia, and Cancer Council of Victoria, Australia. Y.T. is a Scholarship recipient of the Chinese Scholarship Council.