Cellular Microbiology of Mycoplasma canis
Dina L Michaels, Jeffrey A Leibowitz, Mohammed T Azaiza, Pollob K Shil, Suzanne M Shama, Gerald F Kutish, Steven L Distelhorst, Mitchell F Balish, Meghan A May, Daniel R Brown
INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2016
Mycoplasma canis can infect many mammalian hosts but is best known as a commensal or opportunistic pathogen of dogs. The unexpected presence of M. canis in brains of dogs with idiopathic meningoencephalitis prompted new in vitro studies to help fill the void of basic knowledge about the organism's candidate virulence factors, the host responses that it elicits, and its potential roles in pathogenesis. Secretion of reactive oxygen species and sialidase varied quantitatively (P < 0.01) among strains of M. canis isolated from canine brain tissue or mucosal surfaces. All strains colonized the surface of canine MDCK epithelial and DH82 histiocyte cells and murine C8-D1A astrocytes. Transit throug..View full abstract
This work, including the efforts of Daniel R. Brown, was funded by Harold and Vera Morris Trust Research Fund. This work, including the efforts of Daniel R. Brown, was funded by University of Florida College of Veterinary Medicine Faculty Research Development Fund. This work, including the efforts of Jeffrey A. Leibowitz, was funded by University of Florida University Scholars Program.