Journal article

The psychometric and cardiac effects of dimenhydrinate in the hyperbaric environment.

DM Taylor, KS O'Toole, TE Auble, CM Ryan, DR Sherman

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy | Published : 2000

Abstract

STUDY OBJECTIVES: To examine the psychometric and cardiac effects of dimenhydrinate at 1 and 3 atmospheres (atm) of pressure (0 and 66 feet of sea water, respectively), and to make recommendations about the drug's safety in the diving environment. DESIGN: Double-blind, placebo-controlled, crossover study SETTING: Monoplace hyperbaric chamber of a university hospital. SUBJECTS: Thirty active divers (mean age 38 yrs). INTERVENTIONS: A bank of seven tests was used to assess cognitive function during four different dive combinations: placebo-1 atm, placebo-3 atm, dimenhydrinate-1 atm, and dimenhydrinate-3 atm. MEASUREMENTS AND MAIN RESULTS: Heart rate and cardiac rhythm were recorded during all ..

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University of Melbourne Researchers