Journal article

EFFECTS OF SHORT-TERM PULSATILE AND CONTINUOUS INSULIN DELIVERY ON GLUCAGON-SECRETION AND INSULIN-SECRETION AND ACTION

GM WARD, AG MARANGOU, JD BEST, PM AITKEN, FP ALFORD

METABOLISM-CLINICAL AND EXPERIMENTAL | W B SAUNDERS CO | Published : 1989

Abstract

In six normal nonobese subjects, hyperinsulinemic euglycemic clamps were performed during paired sequential two-hour intravenous (IV) insulin infusions separated by an hour washout period. Each infusion was either 32 mU/kg/h of continuous insulin (CI) or 75% of this dose as 40-second pulses delivered every 13 minutes (PI). Six studies were performed with each of the following sequences in random order: PI-CI, CI-PI, and CI-CI. Based on the initial infusions, the insulin-dependent fractional glucose disappearance rate (X) during pulsatile insulin delivery (3.0 +/- 0.4 min-1 X 10(2), n = 6) was 73% of that of the continuous infusions (4.1 +/- 0.3 min-1 X 10(2), n = 12). This ratio was similar ..

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