Journal article

THE EFFECT OF EPINEPHRINE ON GLUCOSE-MEDIATED AND INSULIN-MEDIATED GLUCOSE DISPOSAL IN INSULIN-DEPENDENT DIABETES

JM WALTERS, GM WARD, A KALFAS, JD BEST, FP ALFORD

METABOLISM-CLINICAL AND EXPERIMENTAL | W B SAUNDERS CO | Published : 1992

Abstract

The aim of this study was to determine the relative roles of changes in glucose-mediated glucose disposal (SG) and insulin sensitivity (SI) on the impairment of glucose disposal caused by epinephrine (EPI) infusion in type I (insulin-dependent) diabetes mellitus (IDDM). Seven non-obese young adult diabetics with minimal endogenous insulin secretion had EPI infusions at 25 ng/kg/min for 5.5 hours, after a basal overnight insulin infusion (12 mU/kg/h), and glucose infusion as required to maintain euglycemia. The EPI infusion produced approximately an eightfold increase in plasma EPI. At 2.5 hours, an intravenous glucose tolerance test (IVGTT) was performed with supplemental exogenous insulin i..

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