Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia
Amy M Gratton, Louie Ye, Fiona C Brownfoot, Natalie J Hannan, Clare Whitehead, Ping Cannon, Minh Deo, Peter J Fuller, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
PLACENTA | W B SAUNDERS CO LTD | Published : 2016
INTRODUCTION: Preeclampsia is a serious complication of pregnancy affecting 5% of pregnancies. Our team identified 137 genes highly expressed in placenta relative to other human tissues. Here, we have explored a role for steroid sulfatase (STS) in preeclampsia by characterising STS expression and the functional effects of STS on primary placental trophoblasts. METHODS: Characterisation of STS was performed on preterm preeclamptic and gestation-matched normotensive preterm controls who delivered at <34 weeks gestation. We characterised placental and maternal whole blood STS mRNA and placental protein expression via qRT-PCR, immunohistochemistry and Western Blot. To assess whether STS is invol..View full abstract
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Awarded by National Health and Medical Research Council of Australia
The National Health and Medical Research Council of Australia provided salary (#1062418 to T.K, #1050765 to S.T. and a Senior Principal Research Fellowship to PJF #1002559). N.H salary provided by CR Roper Fellowship. The Hudson Institute is supported by the Victorian Government's Operational Infrastructure Scheme.