Platinum: A database of experimentally measured effects of mutations on structurally defined protein-ligand complexes

Abstract

Drug resistance is a major challenge for the treatment of many diseases and a significant concern throughout the drug development process. The ability to understand and predict the effects of mutations on protein-ligand affinities and their roles in the emergence of resistance would significantly aid treatment and drug design strategies. In order to study and understand the impacts of missense mutations on the interaction of ligands with the proteome, we have developed Platinum (http://structure.bioc.cam. ac.uk/platinum). This manually curated, literaturederived database, comprising over 1000 mutations, associates for the first time experimental information on changes in affinity with three-..