Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes
Douglas EV Pires, Tom L Blundell, David B Ascher
NUCLEIC ACIDS RESEARCH | OXFORD UNIV PRESS | Published : 2015
Drug resistance is a major challenge for the treatment of many diseases and a significant concern throughout the drug development process. The ability to understand and predict the effects of mutations on protein-ligand affinities and their roles in the emergence of resistance would significantly aid treatment and drug design strategies. In order to study and understand the impacts of missense mutations on the interaction of ligands with the proteome, we have developed Platinum (http://structure.bioc.cam.ac.uk/platinum). This manually curated, literature-derived database, comprising over 1000 mutations, associates for the first time experimental information on changes in affinity with three-..View full abstract
Awarded by NHMRC CJ Martin Fellowship
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil [to D.E.V.P.]; NHMRC CJ Martin Fellowship [APP1072476 to D. B. A.]; University of Cambridge and The Wellcome Trust for facilities and support to T.L.B.]. Funding for open access charge: The Wellcome Trust.