Journal article
Bias in Peripheral Depression Biomarkers
AF Carvalho, CA Köhler, AR Brunoni, KW Miskowiak, N Herrmann, KL Lanctôt, TN Hyphantis, J Quevedo, BS Fernandes, M Berk
Psychotherapy and Psychosomatics | KARGER | Published : 2016
DOI: 10.1159/000441457
Abstract
Background: To aid in the differentiation of individuals with major depressive disorder (MDD) from healthy controls, numerous peripheral biomarkers have been proposed. To date, no comprehensive evaluation of the existence of bias favoring the publication of significant results or inflating effect sizes has been conducted. Methods: Here, we performed a comprehensive review of meta-analyses of peripheral nongenetic biomarkers that could discriminate individuals with MDD from nondepressed controls. PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched through April 10, 2015. Results: From 15 references, we obtained 31 eligible meta-analyses evaluating biomarkers in MDD (21,201 cases and ..
View full abstractGrants
Awarded by Brain & Behavior Research Foundation
Awarded by Sao Paulo State Foundation
Awarded by National Council for Scientific and Technological Development (CNPq)
Awarded by CNPq, Brazil
Awarded by NHMRC
Funding Acknowledgements
A.F.C. is supported by a research fellowship award from CNPq (Brazil). C.A.K. is supported by a postdoctoral fellowship from CAPES (Brazil). A.R.B. is supported by the following grants: 2013 NARSAD Young Investigator from the Brain & Behavior Research Foundation (grant No. 20493), 2012 FAPESP Young Researcher from the Sao Paulo State Foundation (grant No. 20911-5), and National Council for Scientific and Technological Development (CNPq, grant No. 470904). J.Q. is the recipient of a research fellowship award from CNPq (Level IA, Brazil). B.S.F. is supported by a scholarship and research grant MCTI/CNPQ/Universal 14/2014 461833/2014-0, both from CNPq, Brazil. M.B. is supported by NHMRC Senior Principal Research Fellowship 1059660. K.W.M. has received consultancy fees from Lundbeck. M.B. has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation, Bristol-Myers Squibb, Eli Lilly, Glaxo SmithKline, Meat and Livestock Board, Organon, Novartis, Mayne Pharma, Servier, and Woolworths, has been a speaker for Astra Zeneca, Bristol-Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi Synthelabo, Servier, Solvay, and Wyeth, and served as a consultant to Astra Zeneca, Bioadvantex, Bristol-Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck Merck, and Servier.