Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways

Abstract

Leukocyte interactions with vascular endothelium during inflammation depend on cascades of adhesion molecule engagement, particularly during selectin-mediated leukocyte rolling. Leukocyte rolling is also facilitated by members of the integrin and Ig families. Specifically, leukocyte rolling velocities during inflammation are significantly increased in ICAM-1- deficient mice, with ICAM-1 expression required for optimal P- and L- selectin-mediated rolling. Elimination of ICAM-1 expression in L-selectin- deficient mice significantly reduces leukocyte rolling. Whether disrupted leukocyte rolling in L-selectin and ICAM-1 double-deficient (L-selectin/ICAM- 1(-/-)) mice affects leukocyte entry into..