Journal article

An integrated map of genetic variation from 1,092 human genomes

David M Altshuler, Richard M Durbin, Goncalo R Abecasis, David R Bentley, Aravinda Chakravarti, Andrew G Clark, Peter Donnelly, Evan E Eichler, Paul Flicek, Stacey B Gabriel, Richard A Gibbs, Eric D Green, Matthew E Hurles, Bartha M Knoppers, Jan O Korbel, Eric S Lander, Charles Lee, Hans Lehrach, Elaine R Mardis, Gabor T Marth Show all

Nature | NATURE PUBLISHING GROUP | Published : 2012

Grants

Awarded by Wellcome Trust


Awarded by Medical Research Council


Awarded by British Heart Foundation


Awarded by National Basic Research Program of China (973 program)


Awarded by Chinese 863 program


Awarded by National Natural Science Foundation of China


Awarded by Shenzhen Key Laboratory of Transomics Biotechnologies


Awarded by Shenzhen Municipal Government of China


Awarded by Guangdong Innovative Research Team Program


Awarded by BMBF


Awarded by Swiss National Science Foundation


Awarded by Biotechnology and Biological Sciences Research Council (BBSRC)


Awarded by German Research Foundation


Awarded by Netherlands Organization for Scientific Research VENI


Awarded by Beatriu de Pinos Program


Awarded by Israeli Science Foundation


Awarded by Genome Quebec and the Ministry of Economic Development, Innovation and Trade


Awarded by National Institutes of Health (NIH)


Awarded by BAA-NIAID-DAIT-NIHAI


Funding Acknowledgements

We thank many people who contributed to this project: A. Naranjo, M. V. Parra and C. Duque for help with the collection of the Colombian samples; N. Kalin and F. Laplace for discussions; A. Schlattl and T. Zichner for assistance in managing data sets; E. Appelbaum, H. Arbery, E. Birney, S. Bumpstead, J. Camarata, J. Carey, G. Cochrane, M. DaSilva, S. Dokel, E. Drury, C. Duque, K. Gyaltsen, P. Jokinen, B. Lenz, S. Lewis, D. Lu, A. Naranjo, S. Ott, I. Padioleau, M. V. Parra, N. Patterson, A. Price, L. Sadzewicz, S. Schrinner, N. Sengamalay, J. Sullivan, F. Ta, Y. Vaydylevich, O. Venn, K. Watkins and A. Yurovsky for assistance, discussion and advice. We thank the people who generously contributed their samples, from these populations: Yoruba in Ibadan, Nigeria; the Han Chinese in Beijing, China; the Japanese in Tokyo, Japan; the Utah CEPH community; the Luhya in Webuye, Kenya; people with African ancestry in the Southwest United States; the Toscani in Italia; people with Mexican ancestry in Los Angeles, California; the Southern Han Chinese in China; the British in England and Scotland; the Finnish in Finland; the Iberian Populations in Spain; the Colombians in Medellin, Colombia; and the Puerto Ricans in Puerto Rico. This research was supported in part by Wellcome Trust grants WT098051 to R. M. D., M. E. H. and C. T. S.; WT090532/Z/09/Z, WT085475/Z/08/Z and WT095552/Z/11/Z to P. Do.; WT086084/Z/08/Z and WT090532/Z/09/Z to G. A. M.; WT089250/Z/09/Z to I. M.; WT085532AIA to P. F.; Medical Research Council grant G0900747(91070) to G. A. M.; British Heart Foundation grant RG/09/12/28096 to C. A. A.; the National Basic Research Program of China (973 program no. 2011CB809201, 2011CB809202 and 2011CB809203); the Chinese 863 program (2012AA02A201); the National Natural Science Foundation of China (30890032, 31161130357); the Shenzhen Key Laboratory of Transomics Biotechnologies (CXB201108250096A); the Shenzhen Municipal Government of China (grants ZYC200903240080A and ZYC201105170397A); Guangdong Innovative Research Team Program (no. 2009010016); BMBF grant 01GS08201 to H. Le.; BMBF grant 0315428A to R. H.; the Max Planck Society; Swiss National Science Foundation 31003A_130342 to E. T. D.; Swiss National Science Foundation NCCR 'Frontiers in Genetics' grant to E. T. D.; Louis Jeantet Foundation grant to E. T. D.; Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I021213/1 to A. R.-L.; German Research Foundation (Emmy Noether Fellowship KO 4037/1-1) to J. O. K.; Netherlands Organization for Scientific Research VENI grant 639.021.125 to K. Y.; Beatriu de Pinos Program grants 2006BP-A 10144 and 2009BP-B 00274 to M. V.; Israeli Science Foundation grant 04514831 to E. H.; Genome Quebec and the Ministry of Economic Development, Innovation and Trade grant PSR-SIIRI-195 to P.Aw.; National Institutes of Health (NIH) grants UO1HG5214, RC2HG5581 and RO1MH84698 to G. R. A.; R01HG4719 and R01HG3698 to G. T. M; RC2HG5552 and UO1HG6513 to G. R. A. and G. T. M.; R01HG4960 and R01HG5701 to B. L. B.; U01HG5715 to C. D. B. and A. G. C.; T32GM8283 to D. Cl.; U01HG5208 to M. J. D.; U01HG6569 to M. A. D.; R01HG2898 and R01CA166661 to S. E. D.; UO1HG5209, UO1HG5725 and P41HG4221 to C. Le.; P01HG4120 to E. E. E.; U01HG5728 to Yu.F.; U54HG3273 and U01HG5211 to R.A.G.; R01HL95045 to S. B. G.; U41HG4568 to S.J.K.; P41HG2371 to W.J.K.; ES015794, AI077439, HL088133 and HL078885 to E. G. B.; RC2HL102925 to S. B. G. and D. M. A.; R01GM59290 to L.B.J. and M. A. B.; U54HG3067 to E. S. L. and S. B. G.; T15LM7033 to B. K. M.; T32HL94284 to J.L.R.-F.; DP2OD6514 and BAA-NIAID-DAIT-NIHAI 2009061 to P. C. S.; T32GM7748 to X. S.; U54HG3079 to R. K. W.; UL1RR024131 to R. D. H.; HHSN268201100040C to the Coriell Institute for Medical Research; a Sandler Foundation award and an American Asthma Foundation award to E. G. B.; an IBMOpen Collaborative Research Program award to Y.B.; an A.G. Leventis Foundation scholarship to D. K. X.; a Wolfson Royal Society Merit Award to P. Do.; a Howard Hughes Medical Institute International Fellowship award to P. H. S.; a grant from T. and V. Stanley to S.C.Y.; and a Mary Beryl Patch Turnbull Scholar Program award to K. C. B. E. H. is a faculty fellow of the Edmond J. Safra Bioinformatics program at Tel-Aviv University. E. E. E. and D. H. are investigators of the Howard Hughes Medical Institute. M. V. G. is a long-term fellow of EMBO.