Journal article

Dedicated C-fibre viscerosensory pathways to central nucleus of the amygdala

Stuart J McDougall, Haoyao Guo, Michael C Andresen

The Journal of Physiology | WILEY | Published : 2017

Abstract

KEY POINTS: Emotions are accompanied by concordant changes in visceral function, including cardiac output, respiration and digestion. One major forebrain integrator of emotional responses, the amygdala, is considered to rely on embedded visceral afferent information, although few details are known. In the present study, we retrogradely transported dye from the central nucleus of the amygdala (CeA) to identify CeA-projecting nucleus of the solitary tract (NTS) neurons for synaptic characterization and compared them with unlabelled, near-neighboor NTS neurons. Solitary tract (ST) afferents converged onto NTS-CeA second-order sensory neurons in greater numbers, as well as indirectly via polysyn..

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Grants

Awarded by National Institutes of Health


Awarded by National Health and Medical Research Council of Australia


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

Supported by grants from the National Institutes of Health; HL-41119 (MCA), HL-105703 (MCA) and Oregon Health & Science University Presidential Bridge Funding (MCA). The National Health and Medical Research Council of Australia CJ Martin Fellowship #400405 (SJM) and the Victorian Government's Operational Infrastructure Support Program (Florey).