Journal article

Acinar cell carcinoma of the pancreas: is the absence of neuroendocrine component related to a more malignant behavior?

Marcel Cerqueira C Machado, Marcel Autran C Machado, Marcos V Perini, Paulo Herman, Jose Jukemura, Katia R Leite, Telesforo Bacchella

HEPATO-GASTROENTEROLOGY | H G E UPDATE MEDICAL PUBLISHING S A | Published : 2008

Abstract

BACKGROUND/AIMS: Acinar cell carcinomas are uncommon malignant tumors of the pancreas, accounting for 1-2% of all the cases of exocrine pancreatic tumor. Some authors have estimated acinar cell tumors to be as aggressive as ductal adenocarcinoma of the pancreas whereas other series showed acinar cell tumors to have a favorable clinical outcome. This discrepancy in prognosis may be related to the cellular components of the tumor. METHODOLOGY: With the aim to evaluate the possible relationship between the presence of neuroendocrine differentiation and behavior of these tumors, the authors reviewed all patients presenting acinar cell carcinoma of the pancreas in the last 5 years with emphasis i..

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University of Melbourne Researchers