Journal article
Aminoguanidine prevents retinal but not glomerular capillary basement membrane thickening in experimental diabetes
CS Mao, N Carroll, S Panagiotopoulos, T Soulis, T Lim Joon, ME Cooper, G Jerums, H Taylor
Investigative Ophthalmology and Visual Science | LIPPINCOTT-RAVEN PUBL | Published : 1996
Abstract
Purpose. Capillary basement membrame thickening (CBMT) has been shown to occur in several tissues in human and experimental diabetes. However a comparison of the retinal and renal ultrastructural effects of diabetes and their response to intervention has not been performed. This study has investigated the effects of aminoguanidine (AG) on retinal and glomerular CBMT in the streptozotocin STZ) diabetic rat. Methods. Three groups of male Sprague Dawley rats, aged 6-8 weeks, were studied; Controls (C) were injected with vehicle, diabetic (D) received STZ, 45mg/kg i.v. and diabetic + AG (D + AG) received STZ as above and AG lg/L of drinking water. At 8 months, the rats were anaesthetized with Ne..
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