Journal article
Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis
CW Huo, M Waltham, C Khoo, SB Fox, P Hill, S Chen, GL Chew, JT Price, CH Nguyen, ED Williams, M Henderson, EW Thompson, KL Britt
Breast Cancer Research | BMC | Published : 2016
Open access
Abstract
Background: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. Methods: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10). HMD and LMD regions of each specimen were resected under radiological guidance. Human MCF10DCIS.com cells, a model of ductal carcinoma in situ..
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Awarded by Movember Foundation
Funding Acknowledgements
This work was supported in part by the Victorian Breast Cancer Research Consortium, the St Vincent's Hospital Melbourne Research Endowment Fund, the National Breast Cancer Foundation and the University of Melbourne Research Grant Support Scheme (MRGSS). CWH was supported by an Australian Postgraduate Award scholarship. GLC was supported by a postgraduate scholarship from the National Health and Medical Research Council. EDW was supported by funding from the Australian Government Department of Health and the Movember Foundation and Prostate Cancer Foundation of Australia through a Movember Revolutionary Team Award. EWT was supported in part by the Australian National Breast Cancer Foundation through the EMPathy National Collaborative Research Program (CG-10-04). KB was supported by a National Breast Cancer Foundation Early Career Fellowship. The study sponsors had no role in the design of the study; the collection, analysis or interpretation of data; or the writing of the manuscript.