Journal article
Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up
WP Brouwer, HLY Chan, MR Brunetto, M Martinot-Peignoux, P Arends, M Cornberg, B Cherubini, AJV Thompson, YF Liaw, P Marcellin, HLA Janssen, BE Hansen
Clinical Gastroenterology and Hepatology | ELSEVIER SCIENCE INC | Published : 2016
Abstract
Background & Aims Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years. Methods We performed a retrospective study of 292 HBe antigen–negative patients with chronic HBV infection, normal levels of alanine aminotransferase (ALT), levels of HBV DNA <20,000 IU/mL, and no cirrhosis who visited the outpatient clinics at 8 tertiary care centers in Europe, Asia, and Australia from 1990 through 2011. Patients were determined to be carriers of inactive HBV (level of HBV DNA 2000 IU/mL and/or abnormal levels of ALT) after eac..
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Awarded by Gilead Sciences
Funding Acknowledgements
The study was organized and sponsored by the Foundation for Liver research, Rotterdam, the Netherlands. An unrestricted grant was provided by Roche (F. Hoffmann-La Roche Ltd, Basel, Switzerland). The funding sources did not have any influence on study design, data collection, analysis and interpretation of the data, writing of the report, nor the decision to submit for publication.