Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles
Yingke He, Mani Baskaran, Arun K Narayanaswamy, Lisandro M Sakata, Renyi Wu, Dianna Liu, Monisha E Nongpiur, Mingguang He, David S Friedman, Tin Aung
British Journal of Ophthalmology | BMJ PUBLISHING GROUP | Published : 2015
AIM: To evaluate quantitative changes in anterior segment optical coherence tomography (AS-OCT) parameters at 4 years in subjects with open angles on gonioscopy at baseline. METHODS: 339 gonioscopically open-angle subjects aged >50 years underwent AS-OCT imaging (Visante, Carl Zeiss Meditec, Dublin, California, USA) at baseline and at 4 years. Customised software was used to analyse images. Linear regression was performed to assess baseline predictors of change in mean trabecular iris space area (TISA). RESULTS: Of the 339 subjects, 204 (61%) had good images for analysis. The mean age at baseline was 60 (SD 6.42) years; 55.4% were women and 87.7% were Chinese. Overall, there was a decrease i..View full abstract
The study was supported by grants from the SingHealth Foundation, Singapore and National Medical Research Council (NMRC), Singapore.