Development of a Score and Probability Estimate for Detecting Angle Closure Based on Anterior Segment Optical Coherence Tomography
Monisha E Nongpiur, Benjamin A Haaland, Shamira A Perera, David S Friedman, Mingguang He, Lisandro M Sakata, Mani Baskaran, Tin Aung
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2014
PURPOSE: To develop a score along with an estimated probability of disease for detecting angle closure based on anterior segment optical coherence tomography (AS OCT) imaging. DESIGN: Cross-sectional study. METHODS: A total of 2047 subjects 50 years of age and older were recruited from a community polyclinic in Singapore. All subjects underwent standardized ocular examination including gonioscopy and imaging by AS OCT (Carl Zeiss Meditec). Customized software (Zhongshan Angle Assessment Program) was used to measure AS OCT parameters. Complete data were available for 1368 subjects. Data from the right eyes were used for analysis. A stepwise logistic regression model with Akaike information cr..View full abstract
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST and the following were reported. Dr. Aung has received research funding, travel support, and honoraria from Carl Zeiss Meditec. Dr Friedman has received an instrument loan from Carl Zeiss Meditec. Supported in part by grants from the National Medical Research Council, Singapore, and the National Research Foundation, Singapore, Republic of Singapore. Involved in Design and conduct of study (M.E.N., B.A.H., D.S.F., T.A.); Data collection (M.E.N., L.M.S., M.B.); Statistical analysis and interpretation (B.A.H., M.E.N., D.F., T.A.); Manuscript preparation and approval (M.E.N., B.A.H., S.A.P., D.S.F., M.H., L.M.S., MB., T.A.); and Provision of patients or resources (S.A.P., M.H., M.B., TA.). The angle closure cases of the validation group were recruited from an on-going randomized controlled trial registered at clinicaltrials.gov under number NCT00347178.