Subgrouping of Primary Angle-Closure Suspects Based on Anterior Segment Optical Coherence Tomography Parameters
Monisha E Nongpiur, Tianxia Gong, Hwee Kuan Lee, Shamira A Perera, Li Cheng, Li-Lian Foo, Mingguang He, David S Friedman, Tin Aung
Ophthalmology | ELSEVIER SCIENCE INC | Published : 2013
PURPOSE: To identify subgroups of primary angle-closure suspects (PACS) based on anterior segment optical coherence tomography (AS-OCT) and biometric parameters. DESIGN: Cross-sectional study. PARTICIPANTS: We evaluated 243 PACS subjects in the primary group and 165 subjects in the validation group. METHODS: Participants underwent gonioscopy and AS-OCT (Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure AS-OCT parameters. An agglomerative hierarchical clustering method was first used to determine the optimum number of parameters to be included in the determination of subgroups. The best number of subgroups was then ..View full abstract
Grants from the Biomedical Research Council, Singapore and the National Medical Research Council, Singapore.