Journal article

Incorporating heterogeneous parent-child environmental effects in biometrical genetic models

Xiaobo Guo, Dungang Liu, Canhong Wen, Mingguang He, Xueqin Wang

Statistics in Medicine | WILEY-BLACKWELL | Published : 2013

Abstract

Heritability is an important index used to measure genetic effects in epidemiologic studies. For estimating heritability, researchers have proposed various statistical models to accommodate different study settings. These models include the ACE or ADE models for classical twin studies and the ACDE model for extended twin family studies. Researchers have shown that the ACDE model is less biased in heritability estimation, because of the utilization of the data of two generations. However, this model simply assumes that all family members, including twins and their parents, are exposed to the same environmental factors. This assumption may not be reasonable in many cases. In this paper, we pro..

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University of Melbourne Researchers

Grants

Awarded by Major State Basic Research Development Program


Awarded by Natural Science Foundation of Guangdong Province, China


Awarded by NSFC


Awarded by NCET


Funding Acknowledgements

We thank two reviewers and the editor for their comments and suggestions that greatly helped improve the presentation of our manuscript. Xueqin Wang received support from the Major State Basic Research Development Program (2012CB517900), Natural Science Foundation of Guangdong Province, China (10151027501000066), NSFC (11001280) and NCET (12-0559).