Journal article
Determinants of lens vault and association with narrow angles in patients from Singapore
GS Tan, M He, W Zhao, LM Sakata, J Li, ME Nongpiur, R Lavanya, DS Friedman, T Aung
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2012
Abstract
• PURPOSE: To describe the distribution and determinants of lens vault and to investigate the association of lens vault with narrow angles. • DESIGN: Prospective cross-sectional study. • METHODS: Phakic subjects 50 years and older were evaluated at a primary healthcare clinic with gonioscopy, partial laser interferometry, and anterior segment optical coherence tomography (AS-OCT). Narrow angles were defined as posterior trabecular meshwork not visible for <2 quadrants on non-indentation gonioscopy. Lens vault was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs on horizontal AS-OCT scans. Analysis of c..
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Funding Acknowledgements
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF Interest. Publication of this article was supported in part by grants from Singhealth, Singapore; the National Medical Research Council, Singapore; and the National Research Foundation, Singapore. Dr Aung has received research funding, travel support, and honoraria from Carl Zeiss Meditec. Dr Friedman has received an instrument loan from Carl Zeiss Meditec. Involved in design of the study (D.F., T.A.); conduct of the study (L.S., R.L., T.A.), statistical analysis (G.T., W.Z., J.L., M.H.); and manuscript preparation (G.A., M.H., W.Z., J.L., M.N., R.L., D.F., T.A.). L.S. was a Glaucoma Fellow at the Singapore Eye Research Institute when the study was being conducted and performed all the AS-OCT measurements. D.F. helped plan the study and was a co-investigator in the grant. He was also involved in the data analysis and manuscript preparation. M.H. developed the software that was used for the AS-OCT measurements and was involved in the analysis of the results. Singapore Eye Research Institute and SingHealth Institutional Review Board Ethics Committee approval was obtained to conduct a prospective cross-sectional study of patients seen at a government primary healthcare clinic. The study adhered to the tenets of the Declaration of Helsinski.