The effect of drinking on atrial natriuretic peptide, vasopressin and thirst appreciation in hyperosmolar man.

Abstract

OBJECTIVES: To assess whether drinking and oropharyngeal stimuli mediate the release of plasma atrial natriuretic peptide (ANP) in man. DESIGN: Hypertonic saline was infused into male volunteers to stimulate thirst. In order to avoid any effect of volume change on ANP release, the studies were performed with the subject in the seated position. SUBJECTS: Seated normal male volunteers (n = 6) were infused with hypertonic saline at a rate of 0.06 ml/kg/min for 90 min on two separate occasions. After a 15-min equilibrium period, subjects were allowed to drink for the following 45-min period on one occasion, but no drinking was permitted on the other occasion. MEASUREMENTS: Aliquots of blood were..