Journal article

Long-term effects of nonpeptide vasopressin V2 antagonist OPC-31260 in heart failure in the rat.

LM Burrell, PA Phillips, J Risvanis, RK Chan, KL Aldred, CI Johnston

American Journal of Physiology | Published : 1998

Abstract

The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. The effect of long-term V2 receptor (V2R) blockade using OPC-31260 was assessed in a rat model of postinfarction-induced CHF. Rats underwent coronary artery ligation or sham operation and were treated for 6 mo with oral OPC-31260 (10 mg . kg-1 . day-1) or vehicle. CHF was characterized by left ventricular remodeling and impaired systolic function, increased cardiac and lung weight, and elevated plasma atrial natriuretic peptide; plasma AVP and plasma renin activity were not increased. Chronic V2R blockade incre..

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