Journal article

EMERGENCE OF MULTIPLY RESISTANT PNEUMOCOCCI

MR JACOBS, HJ KOORNHOF, RM ROBINSBROWNE, CM STEVENSON, ZA VERMAAK, I FREIMAN, GB MILLER, MA WITCOMB, M ISAACSON, JI WARD, R AUSTRIAN

NEW ENGLAND JOURNAL OF MEDICINE | MASS MEDICAL SOC | Published : 1978

Abstract

Multiple antimicrobial resistance in pneumococci was detected in Johannesburg in July, 1977, and prompted an investigation of the prevalence of resistant strains in two hospitals. Carriers of Types 6A and 19A penicillin-resistant pneumococci, resistant to antibiotic concentrations ranging between 0.12 and 4 microgram per milliliter were found in 29 per cent of 543 pediatric patients and 2 per cent of 434 hospital staff members. Multiply resistant Type 19A strains, resistant to beta-lactam antibiotics, erythromycin, clindamycin, tetracycline and chloramphenicol, were isolated from 128 carriers, and were responsible for bacteremia in four patients. Isolates from 40 other carriers were resistan..

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